Chile fell to a 1-0 defeat in Bolivia as their hopes of qualifying for the 2018 World Cup suffered a major blow on Tuesday evening.
Juan Carlos Arce scored the only goal of the game from the penalty spot just before the hour mark after Chile's Marcelo Diaz was penalised for a handball in the area.
Substitute Alejandro Chumacero was sent off for the hosts for a second booking in added time but Bolivia held on in the high altitude of La Paz.
The result means Alexis Sanchez's side sit precariously in the final automatic qualification spot in the South American section - level on points with Argentina who host Venezuela later on Tuesday night.