Arsenal Women will play their high-profile Champions League match against Bayern Munich at Meadow Park in Borehamwood after Uefa granted the club special dispensation.
Emirates Stadium had originally been earmarked to host the Group C tie on 18 December but there was a scheduling clash with Arsenal's men's team.
Mikel Arteta's side have an EFL Cup quarter-final against Crystal Palace on the same date, and it could not be moved because the Eagles have televised Premier League matches on the previous Sunday and the following Saturday.
Meadow Park's facilities do not currently meet Uefa regulations but Arsenal said in a statement that a "unique combination of factors" saw the venue switch approved by European football's governing body.