Arsenal will monitor injury doubts Thomas Partey, Oleksandr Zinchenko and Takehiro Tomiyasu.
Kieran Tierney is following concussion protocol but may be available, while Martin Odegaard and Reiss Nelson are expected to be back in contention.
Emile Smith Rowe is out until December following groin surgery, while Mohamed Elneny is also a long-term absentee.
Tottenham need to assess Dejan Kulusevski, who suffered a muscle issue while away with Sweden.
Captain Hugo Lloris and defender Ben Davies are also doubts after missing international duty, while this game may come too soon for Lucas Moura.
CHRIS SUTTON'S PREDICTION
Arsenal have started the season so well, winning six out of seven league games.