Arsenal are hopeful Hector Bellerin will be fit to play, while Theo Walcott also faces a late fitness test.
Nacho Monreal, Kieran Gibbs and Santi Cazorla are also doubts but Granit Xhaka returns after completing a three-match domestic ban.
Tottenham striker Harry Kane is back in training following an ankle injury but a lack of match fitness means he is unlikely to start.
Moussa Sissoko completes a three-match ban.
It remains to be seen whether Erik Lamela, who missed Tuesday's defeat against Bayer Leverkusen with a hip problem, is fit to play.
MOTD COMMENTATOR'S NOTES
Jonathan Pearce: "In 28 years of commentating on north London derbies I've been certain about one thing.