Arsenal will recall last season's top scorer Pierre-Emerick Aubameyang, who was one of several key players rested against Liverpool in the Carabao Cup.
Cedric Soares returned from injury in that game, while Sokratis is also back in training, but the Gunners still have a number of long-term absentees.
Sheffield United remain without Simon Moore and Lys Mousset, but John Egan is back after completing a one-game ban.
His return is timely as fellow defender Jack O'Connell is ruled out.
The Englishman will be missing for approximately six months following knee surgery.
LAWRO'S PREDICTION
Still no points and no goals for Sheffield United so far this season.