Arsenal could name the same team that began the Community Shield win, with record signing Declan Rice set to play his first league game for the club.
Summer signings Kai Havertz and Jurrien Timber should likewise feature but forward Gabriel Jesus is ruled out as he recovers from minor knee surgery.
Nottingham Forest may hand a debut to former Gunners goalkeeper Matt Turner.
Last season's top scorer Taiwo Awoniyi is back in training but is struggling to recover from an ankle injury.
Anthony Elanga could make his first Forest appearance after moving from Manchester United for £15m this summer.