Arsenal remain without long-term absentees Gabriel Jesus and Mohamed Elneny, while Reiss Nelson and Emile Smith Rowe lack match fitness.
Manchester City will continue to assess injury doubt Erling Haaland, boss Pep Guardiola has said.
The striker was withdrawn at half-time on Sunday following a collision with Aston Villa goalkeeper Emi Martinez.
Defender John Stones is still out with a thigh problem.
MATCH FACTS
Head-to-head
- Arsenal have lost 10 consecutive Premier League games against Manchester City, their longest losing run against one opponent in their league history.