Arsenal winger Bukayo Saka is a major doubt after limping off during their Champions League defeat by Lens.
Gabriel Martinelli is expected to miss a sixth successive game because of a hamstring issue.
Manchester City are without Rodri as the midfielder serves the final game of a three-match ban.
Bernardo Silva is available after returning to the squad in midweek, while John Stones and Kevin de Bruyne have both been ruled out.
MATCH FACTS
Head-to-head
- Arsenal have lost 15 of the past 16 meetings, including 12 consecutive Premier League defeats.