Arsenal manager Mikel Areta says Bukayo Saka is "fine" despite failing to complete Sunday's draw at Manchester City but added "we'll see if he's in the best condition to start or not".
The Gunners' only absentee is Jurrien Timber, who Arteta expects to return before the end of the season.
Luton boss Rob Edwards is unsure whether Alfie Doughty, Reece Burke and Tahith Chong will be fit to play.
A further 10 players are definitely ruled out by injuries.
MATCH FACTS
Head-to-head
- Arsenal won the reverse fixture 4-3 and are vying to complete their first league double against Luton since 1983-84.