Arsenal meet CSKA Moscow at the Emirates in what is their first European quarter-final since they were dumped out of the Champions League in 2010 by Barcelona.
Arsene Wenger's side have not lost the first leg of a European knockout competition since March 1972, when they were beaten by Ajax.
The Gunners are the top-scoring team in the Europa League this season, having recorded an average of 2.3 goals per game.
So how do both sides line up ahead of the crucial fixture?
Check out the confirmed staring XI's below!