Crystal Palace Under-21 head coach and former club captain Paddy McCarthy will manage the first team on Sunday following Patrick Vieira's sacking.
Albert Sambi Lokonga is ineligible to face his parent club, Will Hughes and James McArthur remain doubts because of illness and goalkeeper Vicente Guaita might not be fit to return.
Arsenal defenders Takehiro Tomiyasu and William Saliba were both substituted because of injuries against Sporting.
Saliba's back issue may ease by Sunday.
CHRIS SUTTON'S PREDICTION
On paper you might look at this and think a straightforward home win but it rarely works out that way when Arsenal play Palace.