Mesut Ozil has withdrawn from Germany's friendly against England in Dortmund, alongside Julian Draxler and Mario Gomez.
Arsenal playmaker Ozil and Paris Saint-Germain forward Draxler have both reported hamstring problems, while Wolfsburg striker Gomez has a groin injury.
Germany had already confirmed goalkeeper Manuel Neuer would play no part in Wednesday's match at the Westfalenstadion due to a calf complaint.
"Neuer has reported injured, it's the same with Ozil and Draxler," said Germany boss Joachim Low.
"They have minor hamstring injuries but it is too much of a risk to play them.