Laurent Koscielny will miss the World Cup this summer because of the suspected ruptured Achilles he suffered during Arsenal's Europa League defeat to Atletico Madrid.
The French Football Federation confirmed on Friday evening that the centre-back would not be able to play in Russia.
"It's a very big blow for the France team," coach Didier Deschamps said on www.fff.fr.
The France defender was carried off on a stretcher early on during the 1-0 defeat at the Wanda Metropolitano.
The 32-year-old lost his footing while moving towards Diego Costa off the ball and was in obvious distress as he clutched his lower leg.