Andries Jonker has left his role as Arsenal's academy manager to become Wolfsburg's third boss of the season, after the sacking of Valerien Ismael.
Jonker, 54, returns to Wolfsburg three years after leaving his role as assistant manager to join Arsenal.
"Andries Jonker knows Wolfsburg well and maintained regular contact after his move to London," said Wolfsburg sporting director Olaf Rebbe.
The Dutchman takes over with the club two points above the relegation zone.
Ismael was sacked on Sunday - two days after a 2-1 home defeat by Werder Bremen, their fourth loss in five league games.