With the loss, A-State falls to 17-12 on the season and 9-7 in Sun Belt action, while Louisiana moved to 15-15 overall and 7-9 in the league.
Carlisa May led the way for the Red Wolves with a double-double of 13 kills and 10 digs. Ellie Watkins handed out a game-high 25 assists while Kenzie Fields paced the A-State defense with 12 digs.
The Red Wolves jumped out to an early 4-1 advantage over Louisiana on three kills by May. However, the Cajuns rallied when they went on a 4-0 scoring run to take the lead at 11-7.