The first round of the flu went through the clubhouse during the team's first road trip of the year, when Nick Ahmed and Jeff Mathis were among those who came down with it.
More recently, third baseman Jake Lamb, outfielder David Peralta, quality control coach Robby Hammock and hitting coach Dave Magadan have caught it.
"It's a lot of congestion, heavy chest, maybe a little bit of fever," D-backs manager Torey Lovullo said of the symptoms. "It has been passed around. We feel like we're at the tail end of it again.