The latest came Tuesday night when the right-hander gave up eight runs in 4 2/3 innings as the D-backs fell to the Rockies, 10-5.
It was the D-backs' 10th attempt to reach the .500 mark since April 24, and they are 0-10 now in those games.
Anderson (3-2) came into the game having allowed a total of three runs over his last three starts, and he held the Rockies to one run over the first three innings before the wheels came off in what would become his shortest start of the season.
Nolan Arrenado hit a solo homer in the fourth and then helped key a six-run fifth with a three-run blast.