They do so with Drew Stanton at quarterback. They will look to turn back the clock and lean on running back Adrian Peterson to get them to where they want to be this season.
Niners Nation was nice enough to stop by and give us a look at the 49ers and their trade for Jimmy Garoppolo and how injuries have stagnated their defensive growth.
As for the game... Here is everything you need to know.
WHO?
Arizona Cardinals at San Francisco 49ers
WHEN?