The Arizona Cardinals were at home against the San Francisco 49ers. Going into the game Christian McCaffrey had to be on the Cardinals radar.
In the first game between the 49ers and Cardinals, McCaffrey had 20 carries for 106 yards and three touchdowns. He also was big in the passing game with seven receptions for 71 yards and a touchdown.
The Cardinals did not fair well in this game against McCaffrey. McCaffrey scored three touchdowns which gave him seven against Arizona for the season. This tied the record for most touchdowns against one team during the season.