Arizona is trying to take over the rivalry with St. Louis, winning three of the last four meetings outright, going 4-1 against the spread over the last five. The Cardinals can also take an even firmer grip on the NFC West when they visit the reeling Rams Sunday afternoon.
Point spread: The Cardinals opened as 5.5-point favorites; the total was 44.5 early in the week, according to sportsbooks monitored by Odds Shark (line updates and matchup report).
NFL pick, via Odds Shark computer: 22.3-21.2 Cardinals
Why the Cardinals can cover the spread
Arizona owns a five-game winning streak after holding off San Francisco last week 19-13.