The New York Giants will host the San Francisco 49ers at the MetLife Stadium in East Rutherford, New Jersey at 1 p.m. on Sunday, September 27. This will be the 42nd time the Giants take on the 49ers, with the Giants leading the series 21-20 all-time, including 9-8 at home.
San Francisco should be basking in its recent win against the New York Jets this past Sunday, beating the team 31-13. In its last game, New York finished behind the Chicago Bears 17-13. Both teams are bruised and battered as the two teams in the NFL with the most injuries.