Clemson is 3-0 straight up against Syracuse since the latter joined the ACC as part of the changing college football landscape a few seasons ago. But the Orange are 2-1 against the spread during that span, covering twice as large underdogs. Syracuse once again will be the recipient of a bunch of points when it tussles with the Tigers on Saturday.
Point spread: The Tigers opened as 28.5-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 45.8-20.5 Tigers (College football picks on every game)
Why the Syracuse Orange can cover the spread
The Orange carry a two-game winning streak into this week following their 28-20 upset victory at Boston College last week.