Clemson owns a 15-game Atlantic Coast Conference winning streak, going 8-6-1 against the spread in the process. The Tigers shoot to stay unbeaten on the season and on track for another berth in the College Football Playoff when they host Pittsburgh for an ACC bout Saturday afternoon.
Point spread: The Tigers opened as 19-point favorites, according to sportsbooks monitored by Odds Shark (line updates and matchup report).
College football pick, via Odds Shark computer: 44.6-23.8 Tigers (College football picks on every game)
Why the Pittsburgh Panthers can cover the spread
Pitt had won three straight games but has lost its last two following last week's 51-28 defeat at Miami.