Louisville exploded out of the gate this season with three straight wins and covers, but as word got out, the lines got tougher, and the Cardinals are 0-2-1 against the spread the last three weeks. North Carolina State, meanwhile, playing under the radar, is 4-0 ATS over its last four games. Both teams will try to avoid a second ACC defeat when they meet Saturday afternoon at Papa John's Cardinal Stadium.
Point spread: The Cardinals opened as 20-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 37-23.