Louisville covered three touchdowns last week but larger spreads had been cutting into the Cardinals' profits, forcing a recent 0-2-1 slide against the numbers. Louisville goes against another big number when it visits Virginia on Saturday afternoon in Charlottesville.
Point spread: The Cardinals opened as 27-point favorites, according to sportsbooks monitored by Odds Shark. Line updates and matchup report.
College football pick, via Odds Shark computer: 52.0-17.8 Cardinals (College football picks on every game)
Why the Louisville Cardinals can cover the spread
The Cardinals continued their quest for a berth in the College Football Playoff last week by embarrassing North Carolina State 54-13.