Since becoming ACC divisional rivals Clemson is 4-0 straight up against Louisville, but only 2-2 against the spread, allowing the Cardinals to keep a couple games close as underdogs. Clemson is a huge favorite for Saturday afternoon's meeting with Louisville at Death Valley.
College football point spread: The Tigers opened as 37.5-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 52.3-5.2 Tigers (College football picks on every game)
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