Florida State is 2-1 straight up in its three matchups with its little brother down at South Florida but 0-3 against the spread as the Bulls have given the Seminoles decent games. Coming off one of the worst losses in program history, FSU looks to bounce back when it visits USF on Saturday afternoon in Tampa.
Point spread: The Seminoles opened as 5.5-point favorites, according to sportsbooks monitored by Odds Shark (line updates and matchup report).
College football pick, via Odds Shark computer: 38.4-29.2 Bulls (college football picks on every game)
Why the Florida State Seminoles can cover the spread
Sometimes things happens to teams that can't be explained, and that's the way Florida State should think about last week's 63-20 loss at Louisville.