Florida State is 2-0 both straight up and against the spread in two meetings with Louisville since the teams became ACC rivals, including that wild come-from-behind victory/cover two seasons ago. The Seminoles shoot to make it three in a row over the Cardinals when the teams meet for a big early-season Atlantic Division bout Saturday afternoon at Papa John's Stadium.
Point spread: The Seminoles opened as 4.5-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 38.2-31.4 Cardinals (College football picks on every game)
Why the Florida State Seminoles can cover the spread
The Seminoles are 2-0 SU and 1-0 ATS on the season after disposing of a shorthanded Charleston Southern squad last week 52-8.