Clemson may be a national title contender but it's only 2-3 against the spread at home this season, thanks in part to inflated spreads. Duke, meanwhile, is 4-1 both straight up and ATS on the road this year. Who's the smart bet for Saturday night's Tigers-Blue Devils clash at Death Valley?
College football point spread: The Tigers opened as 27-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 52.3-18.6 Tigers (College football picks on every game)
Check out the OddsShark podcast on iTunes or Spotify or at OddsShark.