The Clemson Tigers own a 12-game road winning streak, but they're only 6-6 against the spread over that run, playing against some stiff numbers.
The Tigers are lined as heavy road favorites for their tangle with the Syracuse Orange on Friday night at the Carrier Dome.
College football point spread: The Tigers opened as 21.5-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 49.2-14.0 Tigers (College football picks on every game)
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