Clemson is 3-0 straight up against Louisville since the latter joined the Atlantic Coast Conference a few seasons ago, but the Cardinals are 2-1 against the spread and gave the eventual national champions a good scare last year at Death Valley. In a big game in the ACC's Atlantic Division, Louisville challenges the national champion Tigers on Saturday afternoon at Papa John's Stadium.
College football point spread: The Tigers opened as 2.5-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 41.