The Clemson Tigers are 5-0 in their last five meetings with Boston College, but they're only 2-3 against the spread because they've been favored by so much. Coming off a huge victory at home, the Tigers hit the road on a short week to take on the Eagles in Chestnut Hill on Friday night.
Point spread: The Tigers opened as 17-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, per the Odds Shark computer: 38.6-15.4 Tigers (College football picks on every game)
Why Clemson can cover the spread
Clemson just won the game of the year (so far) in college football, outlasting Lamar Jackson and Louisville 42-36 in Death Valley.