The last time Clemson played Pittsburgh, two seasons ago, it suffered an outright upset as a 21-point favorite. The Tigers are favored by even more than that for Saturday night's clash with the Panthers in the ACC championship game in Charlotte.
College football point spread: The Tigers opened as 20-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 53.0-19.1 Tigers (College football picks on every game)
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