Rafael Nadal's hopes of winning a third Wimbledon title are over for another year after an epic five-set defeat by 16th seed Gilles Muller of Luxembourg.
Spaniard Nadal, a 15-time Grand Slam champion, fought back from two sets down before Muller took a fifth match point to win 6-3 6-4 3-6 4-6 15-13.
It ended Nadal's hopes of winning back-to-back French Open and Wimbledon titles for a joint-record third time.
Muller, 34, will play Croatia's seventh seed Marin Cilic in the last eight.
"That was tough," said Muller, who has reached his first Grand Slam quarter-final since the 2008 US Open.