Instant Reaction: Peyton Manning Makes History As Broncos Blow Out 49ers, 42-17

Broncos QB Peyton Manning stole the show Sunday night, as he came into the game needing three passing touchdowns to break Brett Favre's record for most career touchdown passes.

He made quick work of San Francisco's defense, accomplishing the feat late in the second quarter.

WATCH: Peyton Manning Breaks Brett Favre's Record For Career Touchdown Passes

Manning and the Broncos were able to carve up San Francisco's defense all night, taking a 21-10 lead into halftime before really blowing the game open in the second half as they cruised to the easy victory.

Turning Point:

San Francisco had managed to cut Denver's lead to 21-10 right before the half, stalling the momentum from Manning's record breaking touchdown pass. However, the Broncos took the game over for good when Demaryius Thomas scored a 40-yard touchdown on the play after Colin Kaepernick was picked off on San Francisco's first drive of the third quarter.

Key Stat:

The stat that's greater than anything that happened in this game is 509 touchdowns, but the biggest difference to the outcome of this game can be seen in each teams' total rushing yards. San Francisco's inability to run the ball (62 yards on the ground) took them out of their gameplan and didn't allow them to control the ball.

Denver MVP:

Is there really any question? The NFL's new touchdown king had himself a game, completing 22 of his 26 passes for 318 yards and four touchdowns, bringing his career total to 510. Manning managed to accomplish all of that in just three quarters, as Denver pulled their starters in the blowout.

San Francisco MVP:

Tonight was all about Peyton Manning, but Kaepernick had a pretty nice game, too. He went 24/39 for 263 yards and a touchdown, and was the only productive Niners player on the night.

What’s Next?

Denver has a short week, facing San Diego on Thursday night in a battle for first place in the AFC West. San Francisco has now fallen two games back in the NFC West, and have a bye week to regroup before facing the Rams on November 2.

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