I'm a big fan of the matchup defense, meaning you choose your defense based more on who the defense is playing than the defense itself. The byes shouldn't hurt your options too badly this week. I list the top 10 only because I base my rankings on a standard, 10-team league.
Byes: Kansas City Chiefs & New Orleans Saints
Last Update: Oct. 9
Other Rankings: QB, RB, WR, TE, DEF
| Rank & Team | Opponent | Notes |
| 1. Chargers | @OAK | Great matchup for the Super Chargers. |
| 2. Bengals | CAR | I'm thinking the Bengals bounce back in a big way against the Panthers. |
| 3. Broncos | @NYJ | Great matchup for a good defense. |
| 4. 49ers | @STL | The 49ers defense has done well so far and this is a good matchup. |
| 5. Seahawks | DAL | If you have the Seahawks defense, you're probably starting them every week. |
| 6. Titans | @JAC | The Jaguars are terrible. |
| 7. Lions | @MIN | The Lions defense has been really good this season. |
| 8. Cardinals | WAS | I like the Cardinals defense and don't like the Redskins offense. |
| 9. Ravens | @TB | If you're desperate, this is an acceptable play. |
| 10. Patriots | @BUF | The Patriots are a decent play this week. |