If the Carolina Panthers are going to match their best start in franchise history, they’re going to have to do something they haven’t done since 2007: defeat the Seattle Seahawks.
| Date | Location | Result | Notes |
| 1/10/2015 | Seattle | L, 17-31 | Russell Wilson throws 3 touchdowns; Kam Chancellor scores a pick-six |
| 10/26/2014 | Carolina | L, 9-13 | Luke Willson scored the game-winning touchdown with 53 seconds left |
| 9/8/2013 | Carolina | L, 7-12 | Jermaine Kearse's fourth-quarter touchdown gives Seattle the win |
| 10/7/2012 | Carolina | L, 12-16 | Panthers held to 190 yards of offense |
| 12/5/2010 | Seattle | L, 14-31 | Marshawn Lynch scores three touchdowns |
The Panthers have come frustratingly close to beating a team that has ranked among the top teams in the NFL since 2010; only the New England Patriots, Green Bay Packers and Baltimore Ravens have won more games than Seattle since 2010.